Table 2.

Association of candidate gene DNA markers with physiological stress parameters in the synthetic (SYN) line

Gene	Genotype		Genotype		Genotype
Trait*	LSM1,2	SE1	LSM	SE	LSM	SE	p-value
	(n)		(n)		(n)		q-value3
RYR1 c.1843C>T	CC		CT		TT
Glucose (mmol/l)	13.9	0.33	13.0	0.44	na4		0.038
	(275)		(140)				0.21
Lactate (mmol/l)	10.1	0.23	11.5	0.31	na		<0.0001
	(276)		(140)				<0.0001
CK (log10(U/l))	3.55	0.02	3.79	0.03	na		<0.0001
	(275)		(135)				<0.0001
Cortisol (ng/ml)	53.7	1.40	49.2	1.89	na		0.020
	(276)		(140)				0.17
CRH g.233C>T	CC		CT		TT
Glucose (mmol/l)	13.8e	0.40	12.8a,f	0.39	14.6b	0.58	0.002
	(143)		(204)		(65)		0.04
CK (log10(U/l))	3.63e	0.03	3.69	0.03	3.73f	0.04	0.055
	(142)		(199)		(66)		0.27
NR3C1 c.*2122A>G	AA		AG		GG
Cortisol (ng/ml)	46.6c	2.27	52.1d	1.58	52.7d	2.02	0.024
	(92)		(210)		(96)		0.18

¹LSM: least square mean; SE: standard error

² LSM with different superscripts ^{a,b; c,d; e,f} differ at p < 0.01; p < 0.05; and p < 0.1 respectively

³q-value: false discovery rate

⁴na: not available or not analyzed due to low frequency n < 10;