Table 4.

Association of candidate gene DNA markers with aggressive behaviour in the synthetic (SYN) line

Gene	Genotype		Genotype		Genotype		p-value
Trait	LSM1,2	SE1	LSM	SE	LSM	SE	q-value3
	(n)		(n)		(n)
RYR1 c.1843C>T	CC		CT		TT
Rear Lesions (log10 LS)	0.87	0.027	0.95	0.035	na4		0.032
	(255)		(132)				0.19
CRH g.233C>T	CC		CT		TT
Rear Lesions (log10 LS)	0.86e	0.035	0.92	0.031	0.99f	0.051	0.085
	(134)		(189)		(61)		0.33
CRHBP c.51G>A	GG		GA		AA
Middle Lesions (log10 LS)	1.22	0.026	1.31	0.051	na		0.060
	(329)		(69)				0.27
NR3C1 c.*2122A>G	AA		AG		GG
Total Lesions (log10 LS)	1.69e	0.035	1.68e	0.024	1.59f	0.033	0.045
	(80)		(174)		(83)		0.24
Front Lesions (log10 LS)	1.15c	0.046	1.12c	0.032	0.99d	0.044	0.012
	(85)		(190)		(88)		0.13
AVPR1B c.1084A>G	AA		AG		GG
Total Lesions (log10 LS)	1.68	0.021	1.57	0.034	na		0.003
	(271)		(82)				0.04
Front Lesions (log10 LS)	1.11	0.028	1.02	0.047	na		0.061
	(295)		(86)				0.27
Middle Lesions (log10 LS)	1.25	0.026	1.13	0.045	na		0.007
	(309)		(90)				0.08
UCN g.1329T>C	TT		TC		CC
Front Lesions (log10 LS)	1.07	0.028	1.17	0.045	na		0.029
	(285)		(90)				0.19

¹LSM: least square mean; SE: standard error

²LSM with different superscripts ^{a,b; c,d; e,f} differ at p < 0.01; p < 0.05; and p < 0.1 respectively

³q-value: false discovery rate

⁴na: not available or not analyzed due to low frequency n < 10;