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Conventional warping and high-dimension-warping of a SPECT image in an MSA-C patient. T2-weighted MRI (A) showed severe atrophy in cerebellum and pons in a 56-year-old woman with MSA-C. A SPECT image at the level of the pons (B) demonstrated perfusion decrease in the cerebellum and pons. In contrast to conventional warping (D), high-dimension-warping (E) achieved sufficient spatial normalization to a template (C) using a contraction map (F).
