TABLE 2.

Neonatal Characteristics of THOP Study Subjects According to Treatment Arm

Neonatal Characteristic	Placebo (25 Women; 27 Subjects)	Iodine (24 Women; 24 Subjects)	Bolus 4 μg/kg per d (24 Women; 24 Subjects)	Continuous 4 μg/kg per d (24 Women; 24 Subjects)	Bolus 8 μg/kg per d (19 Women; 20 Subjects)	Continuous 8 μg/kg per d (24 Women; 25 Subjects)	Total (129 Women; 144 Subjects)
Birth weight, g
Mean ± SEM	865 ± 35	870 ± 41	852 ± 44	888 ± 48	860 ± 39	819 ± 31	859 ± 16
Median	870	845	840	825	821	800	835
Range	558–1300	440–1325	460–1340	560–1550	530–1246	499–1190	440–1550
Gestational age, wk
Mean ± SEM	26 ± 0.2	26 ± 0.2	26 ± 0.2	26 ± 0.2	26 ± 0.2	26 ± 0.2	26 ± 0.1
Median	27	26	26	27	26	26	26
Range	24–28	24–28	24–28	25–28	24–28	24–27	24–28
Hormone levels at birth, mean ± SEM
FT4, ng/dL	1.5 ± 0.1	1.6 ± 0.2	1.5 ± 0.1	1.4 ± 0.1	1.6 ± 0.2	1.3 ± 0.1	1.5 ± 0.1
TT4, μg/dL	6.5 ± 0.5	6.3 ± 0.7	8.1 ± 0.7a	6.5 ± 0.4	7.2 ± 0.7	6.0 ± 0.5	6.7 ± 0.2
T3, ng/dL	64 ± 7	61 ± 7	92 ± 9a	65 ± 4	72 ± 10	62 ± 8	69 ± 3
Thyrotropin, mIU/L	5.8 ± 0.7	4.6 ± 0.9	5.2 ± 0.8	4.8 ± 0.5	3.9 ± 0.7	5.5 ± 1.0	5.0 ± 0.3
Male, n (%)	18 (67)	13 (54)	13 (54)	10 (42)	12 (60)	16 (64)	82 (57)
Cesarean delivery, n (%)	13 (48)	5 (21)	13 (54)	11 (46)	11 (55)	8 (32)	61 (42)
Multiple birth, n (%)
Singleton	20 (74)	20 (83)	18 (75)	18 (75)	16 (80)	18 (72)	110 (76)
Twins or triplets	7 (26)	4 (17)	6 (25)	6 (25)	4 (20)	7 (28)	34 (24)
Apgar score at 5 min of < 7, n (%)	4 (15)	2 (8)	6 (25)	5 (21)	6 (30)	6 (24)	29 (20)

The total number of mothers is <144, because 1 mother can appear in up to 3 arms depending on her neonate's treatment assignment as a consequence of multiple gestation.

^aP < .05 for the occurrence of the sign or the mean of the variable in this arm is significantly different from that seen across all study arms.