Table 2. Model parameters for transitions between different enzyme states for the reaction scheme in Fig. 1b.

	E→ES1 E→ES2	ES1→E ES2→E	ES1→ES1S2 ES2→ES1S2	ES1S2→ES1 ES1S2→ES2	ES1S2→E+P (catalysis)
	20	20	8	8	10
	3	3	6	6	3
	0.65	0.65	−0.65	−0.65	0.65
	11.1	11.1	11.1	11.1	11.1