Table 2.
Sequence conservation of four selected siRNA targets in 327 HBV strains
| Genotype (No. of HBV strains) |
Number of strains with identical sequence with siRNA(%) |
Subtype (No. of HBV strains) |
|||
|---|---|---|---|---|---|
| B245 | B376 | B1581 | B2379 | ||
| Genotype A (63) | 61(96.8) | 62(98.4) | 62(98.4) | 63(100) | Aa(45), Ac(9), Ae(9) |
| Genotype B(72) | 69(95.8) | 49(68.1)* | 71(98.6) | 70(97.2) | Bj(9), Ba(38), B3(7), B4(8), B5(4), B6(6) |
| Genotype C(58) | 53(91.4) | 46(79.3)* | 57(98.3) | 56(96.6) | C1(38), C2(13), C3(2), C4(2), C5(3) |
| Genotype D(30) | 29(96.7) | 29(96.7) | 28(93.3) | 28(93.3) | D1(11), D2(6), D3(8), D4(5) |
| Genotype E(34) | 33(97.1) | 34(100) | 33(97.1) | 33(97.1) | F1(4), F2(14) |
| Genotype F(18) | 15(83.3) | 18(100) | 18(100) | 18(100) | |
| Genotype G(17) | 17(100) | 17(100) | 15(88.2) | 16(94.1) | |
| Genotype H(13) | 13(100) | 13(100) | 12(92.3) | 13(100) | |
| Genotype I(22) | 21(95.5) | 22(100) | 22(100) | 22(100) | I1(10), I2(12) |
| Total (327) | 311(95.1) | 290(88.7)* | 318(97.3) | 319(97.6) | |
a: An asterisk represents a statistical difference of P < 0.05 in comparison with B376 and others.