Table 1. Multivariate analysis for classification into TB cases, TST+ or TST− contacts.
Antigen | Cytokines | % Sensitivity | % Specificity | % Correct classification |
TB Cases versus TST+ HHC | ||||
PPD | IFN-γ | 94 | 33 | 74 |
IL-12(p40)+IL-13 | 89 | 56 | 77 | |
TNF-α+IL-12(p40)+IL-13 | 94 | 56 | 81 | |
EC | IL-12(p40) | 97 | 44 | 81 |
IL-12(p40)+IL-10 | 91 | 50 | 79 | |
IL-12(p40)+TNF-α+IL-17 | 94 | 44 | 79 | |
TB10.4 | IFN-γ | 92 | 44 | 76 |
TNF-α+IL-12(p40) | 97 | 56 | 83 | |
TNF-α+IL-12(p40)+IL-17 | 97 | 61 | 85 | |
TST+ versus TST− HHC | ||||
PPD | IFN-γ | 69 | 71 | 70 |
IFN-γ+IL-10 | 69 | 77 | 73 | |
IFN-γ+IL-10+IL-12(p40) | 69 | 77 | 73 | |
EC | IFN-γ | 72 | 61 | 67 |
IFN-γ+IL-13 | 67 | 72 | 69 | |
IFN-γ+IL-17+IL-18 | 72 | 72 | 72 | |
TB10.4 | IFN-γ | 83 | 65 | 74 |
IFN-γ+IL-12(p40) | 78 | 65 | 71 | |
IFN-γ+IL-12(p40)+IL-17 | 83 | 59 | 71 |