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. 2010 Aug 6;10:25. doi: 10.1186/1472-6807-10-25

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Copyright ©2010 Inuzuka et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Loss of a wall surrounding hydrophobic pockets in ALG-2^ΔGF122. Surface structures of (A) Ca²⁺-bound des3-20ALG-2, (B) Ca²⁺-bound des3-23ALG-2^ΔGF122, (C) Zn²⁺-bound ALG-2, and (D) Zn²⁺-bound des3-20ALG-2^F122Aare presented in gray except for indicated residues of Gly¹²¹Phe¹²²(green), G123 (or G121 in des3-23ALG-2^ΔGF122) (magenta), A122 in the F122A mutant (orange), R125 (or R123 in des3-23ALG-2^ΔGF122) (cyan), Y180 (or Y178 of des3-23ALG-2^ΔGF122) from a dimerized counterpart molecule (yellow).