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. 2010 Aug 6;10:25. doi: 10.1186/1472-6807-10-25

Table 2.

Intramolecular interactions of ALG-2 in Ca2+/EF3-driven arginine switching loop

WT ΔGF122

interacting atom MF a Ca b Ca c
S120
Hydrogen Distance (Å)

N OK116 2.8 3.2 3.1
O NG123/121 2.8 2.8 NDd
NH2R125/123 ND 2.8 ND
OG OL116 2.6 ND ND
Y124/122
hydrogen
N OL119 3.1 3.0 3.0
OH NE2Q159/157 ND ND 2.8
hydrophobic
CB CL119 ND 3.9 ND
CD1L126/124 3.9 3.7 3.9
CGL126/124 ND ND 3.7
CD1 CBF122/- 3.7 3.6 -e
CD1L158/156 ND ND 4.0
CD2 CD2L158/156 3.9 ND ND
CE1 CBF122/- 3.8 3.8 -
CD1F122/- 3.9 ND -
CD2L158/156 3.9 ND ND
CE2 CGL158/156 3.5 ND ND
CD2L158/156 3.7 3.8 ND
CZ CD1L158/156 ND 4.0 ND

a Metal-free form of des3-20ALG-2

b Ca2+-bound form of des3-20ALG-2

c Ca2+-bound form of des3-23ALG-2ΔGF122

d Not detected in the range of 2.6-3.2 Å for hydrogen bonding and 3.2-4.0 Å for hydrophobic interaction

e Not present in des3-23 ALG-2ΔGF122