Table 3.

 Age and multivariable* adjusted hazard ratios (95% confidence intervals) for mortality from cardiovascular disease according to migraine status in men and women in Reykjavik Study (n=18 725†)

	No headache	Non-migraine headache‡	Migraine	Migraine without aura§	Migraine with aura¶
Men
Died/total	2086/7068	388/1405	189/571	38/128	151/443
Age adjusted	1.00	0.99 (0.89 to 1.10)	1.28 (1.11 to 1.49)**	1.07 (0.78 to 1.48)	1.35 (1.15 to 1.60)**
Multivariable adjusted	1.00	0.97 (0.87 to 1.08)	1.35 (1.17 to 1.57)**	1.14 (0.83 to 1.57)	1.42 (1.20 to 1.68)**
Women
Died/total	1061/6003	377/2226	222/1452	66/498	156/954
Age adjusted	1.00	1.12 (1.00 to 1.26)	1.15 (0.99 to 1.33)	1.04 (0.81 to 1.34)	1.20 (1.01 to 1.42)**
Multivariable adjusted	1.00	1.13 (1.01 to 1.27)**	1.16 (1.00 to 1.34)	1.09 (0.85 to 1.40)	1.18 (1.00 to 1.40)
Men and women
Died/total	3147/13 071	765/3631	411/2023	104/626	307/1397
Age-sex adjusted	1.00	1.04 (0.96 to 1.13)	1.19 (1.07 to 1.32)**	1.02 (0.84 to 1.24)	1.25 (1.11 to 1.41)**
Multivariable adjusted	1.00	1.04 (0.96 to 1.13)	1.22 (1.10 to 1.36)**	1.10 (0.91 to 1.34)	1.27 (1.13 to 1.43)**

*Age, BMI, smoking (no, current, previous), education (primary, secondary, college/university), systolic and diastolic blood pressure, use of antihypertensive drugs, cholesterol concentration, diabetes, history of coronary artery disease, and birth control use for women.

†Of original 18 903 participants, 68 (0.36%) were lost to follow-up and 110 (0.58%) had missing data on blood pressure, cholesterol concentration, or BMI, leaving n=18 725 with 470 990 years of follow-up.

‡Headache without or with one symptom of migraine once or more a month.

§2-3 of unilateral, photophobia, nausea symptoms.

¶Migraine with visual or sensory symptoms, or both. Participants with symptoms of migraine without aura and migraine with aura were classified as migraine with aura.

**Significant at P<0.05.