Table 3.

Risk of incident AF according to birth weight categories, censoring women at their first cardiovascular event

	Birth weight category, in kg
	<2.5 (n=2962)	2.5 – 3.2 (n=7228)	3.2 – 3.9 (n=14214)	3.9 – 4.5 (n=2785)	≥4.5 (n=793)	p_{linear trend}
Number of events	52	161	348	96	32	-
Age-adjusted incidence rate	1.32	1.74	1.81	2.53	2.43	-
Age-adjusted relative risk	Referent	1.34 (0.98–1.83)	1.38 (1.03–1.85)	1.89 (1.35–2.65)	1.83 (1.17–2.84)	0.0002
Multivariable model 1^*	Referent	1.34 (0.98–1.84)	1.32 (0.98–1.77)	1.81 (1.29–2.55)	1.75 (1.12–2.73)	0.001
Multivariable model 2^†	Referent	1.33 (0.97–1.83)	1.29 (0.96–1.74)	1.77 (1.26–2.50)	1.65 (1.06–2.58)	0.003
Multivariable model 3^‡	Referent	1.30 (0.94–1.78)	1.15 (0.85–1.55)	1.49 (1.05–2.11)	1.34 (0.86–2.10)	0.14
Multivariable model 4^§	Referent	1.28 (0.93–1.76)	1.12 (0.83–1.50)	1.47 (1.04–2.08)	1.29 (0.82–2.02)	0.19

Data are counts, rates per 1000 person-years of follow-up or hazard ratios (95% confidence intervals)

Adjusted for age, hypercholesterolemia, smoking, exercise, alcohol consumption, education, race/ethnicity and hormone replacement therapy. Due to missing covariates, the multivariable model was based on 670 events in 27174 women.

^†

Additionally adjusted for body mass index, systolic blood pressure, diastolic blood pressure and diabetes. Due to missing covariates, the multivariable model was based on 651 events in 26368 women.

^‡

Additionally adjusted for adult height. Due to missing covariates, the multivariable model was based on 651 events in 26368 women.

^§

Additionally adjusted for maximum body weight between ages 18 and 30 years. Due to missing covariates, the multivariable model was based on 644 events in 25992 women.