Figure 1.—

Molecular cloning and sequence analysis of dph-3 defined by a lin-1(e1275) suppressor mutation. (A) Cartoon of the dph-3 location relative to mapping marker and rescuing DNA clones and regions uncovered by the two deletion mutations. (B) Protein alignment of DPH-3 and its orthologs in other representative eukaryotes. The orthologs are Homo sapiens (HsDPH3), Xenopus laevis (xDPH3), Drosophila melanogaster (CG14701), and S. cerevisiae (Kti11p). Alignment of multiple protein sequences was produced by Clustalw (http://align.genome.jp/) and edited manually by using GENEDOC (http://www.nrbsc.org/gfx/genedoc/).