Table 3.
Gender specific distribution of ADD1 (Gly460Trp) gene polymorphism among cases and controls
| Gly460Trp | Male |
Female |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 212) | Controls (n = 210) | OR (95% CI) | P value | ORa (95% CI) | P value | Cases (n = 220) | Controls (n = 251) | OR (95% CI) | P | ORa (95% CI) | P value | |
| Genotype | ||||||||||||
| Gly/Gly | 126 (59.4) | 139 (66.2) | 1.0 | Ref | 1.0 | Ref | 129 (58.6) | 154 (61.4) | 1.0 | Ref | 1.0 | Ref |
| Gly/Trp | 75 (35.4) | 65 (31.0) | 1.3(0.8-1.9) | 0.3 | 1.2 (0.8-1.8) | 0.4 | 79 | 84 (33.5) | 1.1 (0.8-1.7) | 0.6 | 1.1 (0.8-1.8) | 0.5 |
| Trp/Trp | 11 (5.2) | 6 (2.8) | 2.0(0.7-5.6) | 0.2 | 2.0 (0.7-5.7) | 0.2 | (35.9) | 13 (5.2) | 1.1 (0.4-2.4) | 0.9 | 0.9 | |
| Allele | 12 (5.5) | 1.1 (0.5-2.6) | ||||||||||
| Gly | 0.77 | 0.82 | 1.3(0.9-1.8) | 0.1 | 0.77 | 0.79 | 1.1(0.8-1.5) | 0.6 | ||||
| Trp | 0.23 | 0.18 | 0.23 | 0.21 | ||||||||
Values in parenthesis indicate percentage
a
Odds ratio according to genotype was estimated after adjusting the cofounding variables for smoking and alcohol consumption in male subjects and for age in female subjects.