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A 179-aa region containing the N-terminal SANT domain of CoREST is required for interaction with HDAC1. (A) Four different deletion constructs were generated to map potential HDAC1-interacting regions. (B) Coimmunoprecipitation–Western blot experiments demonstrate that a 179-aa region containing the N-terminal SANT domain of CoREST is required for association with HDAC1. (C) ΔNsant-F lacks associated histone deacetylase activity.
