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The self inactivating lentiviral vector, FancA-sW, includes a phosphoglycerate kinase (PGK) promoter, the human FancA coding sequence, and a synthetic woodchuck hepatitis virus posttranscriptional regulatory element (sW). As an additional safety feature the sW was modified to interrupt a partial woodchuck hepatitis virus X protein open reading frame. LTR is long terminal repeat, CAR is lentiviral cis-acting region.
