A: The structures of 8,9-EET and the analogs tested. B: Survival of control or serum deprived PASMCs treated with 8,9-EET and analogs. Only the 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog(214)) improved survival (for each group n= 6; #p<0.05 compared with SD). C: Survival of starved pulmonary artery endothelial cells was increased by native 8,9-EET but not 8,9-EET analog(214) (n=12; *p<0.05 compared with Control; #p<0.05 compared with 8,9-EET).