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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Exp Cell Res. 2010 May 21;316(14):2340–2353. doi: 10.1016/j.yexcr.2010.05.013

Fig. 6.

Fig. 6

8,9-EET analog(214) inhibits the caspase-3 activation, the expression of caspase-9 and cleavage of procaspase-3 through ROCK pathway. A: The expression of caspase-9 in rat PASMCs. B: The expression of procaspase-3 in rat PASMCs. C: The activity of Caspase-3 in rat PASMCs. 8,9-EET analog(214) decreased the activity of caspase-3, suppressed the cleavage of procaspase-3 and reduced the expression of caspase-9 in PASMCs under serum deprivation. However, its inhibitory effects were abolished after blocking the ROCK pathway with Y-27632 or HA-1077. “SD” means serum deprivation. All values are denoted as means ± S.E.M. from three or more independent batches of cells (*p<0.05 compared with Control; #p<0.05 compared with SD).