Table 2.
Genotype / Allele | Parents | Siblings | Probands |
---|---|---|---|
CCR5 -1835 C/C | 715 (79.4 %) | 368 (82.9%) | 546 (81.7%) |
CCR5-1835 C/T | 158 (17.6 %) | 58 (13.1%) | 104 (15.6%) |
CCR5-1835 T/T | 5 (0.6 %) | 2 (0.5%) | 4 (0.6%) |
CCR5-1835 C allele frequency | 90. 4 % | 92.8 % | 91.4 % |
CCR5-1835 T allele frequency | 9.6 % | 7. 2% | 8.6 % |
CCR5 WT/WT | 948 (82.0 %) | 446 (80.8 %) | 692 (83.1 %) |
CCR5 WT/ Δ32 | 190 (16.4 %) | 98 (17.8 %) | 135 (16.2 %) |
CCR5 Δ32 /Δ32 | 18 (1.6 %) | 8 (1.4 %) | 6 (0.7 %) |
CCR5 WT allele frequency | 90.2 % | 89.7 % | 91.2 % |
CCR5 Δ32 allele frequency | 9.8 % | 10.3 % | 8.8 % |
Allele and genotype frequencies were calculated from parents, unaffected siblings and cases from the simplex and multiplex JRA cohorts.