Table 2.

Distribution of CCR5 genotypes in JRA families

Genotype / Allele	Parents	Siblings	Probands
CCR5 -1835 C/C	715 (79.4 %)	368 (82.9%)	546 (81.7%)
CCR5-1835 C/T	158 (17.6 %)	58 (13.1%)	104 (15.6%)
CCR5-1835 T/T	5 (0.6 %)	2 (0.5%)	4 (0.6%)
CCR5-1835 C allele frequency	90. 4 %	92.8 %	91.4 %
CCR5-1835 T allele frequency	9.6 %	7. 2%	8.6 %
CCR5 WT/WT	948 (82.0 %)	446 (80.8 %)	692 (83.1 %)
CCR5 WT/ Δ32	190 (16.4 %)	98 (17.8 %)	135 (16.2 %)
CCR5 Δ32 /Δ32	18 (1.6 %)	8 (1.4 %)	6 (0.7 %)
CCR5 WT allele frequency	90.2 %	89.7 %	91.2 %
CCR5 Δ32 allele frequency	9.8 %	10.3 %	8.8 %

Allele and genotype frequencies were calculated from parents, unaffected siblings and cases from the simplex and multiplex JRA cohorts.