. Author manuscript; available in PMC: 2010 Aug 25.

Published in final edited form as: Genes Immun. 2006 Jun 15;7(6):468–475. doi: 10.1038/sj.gene.6364317

Table 4.

Results of transmission disequilibrium testing for transmission of the CCR5-Δ32 allele

JRA phenotype	Number of families	Number of affected	CCR5 WT		CCR5-Δ 32		P¹
JRA phenotype	Number of families	Number of affected	Observed	Expected	Observed	Expected	P¹
All JRA	697	819	1493	1486	145	152	0.36
Pauciarticular	346	409	746	738	72	80	0.14
Polyarticular	283	303	543	547	63	59	0.47
Systemic	104	104	198	194	10	14	0.08
Early onset²	405	459	850	839	68	79	0.05
Late onset²	327	355	634	637	76	74	0.66
Unaffected siblings³	348	548³	984	989	112	107	0.46

P values were calculated by bootstrap simulation based on 10,000 samples.

Early onset was defined as onset before age 6, and late onset was defined as onset at 6 years or later

Children with JRA were excluded from this analysis, and only families with unaffected siblings of children with JRA were used for this analysis.