Table 2.

Effect of ALT-836 on hematological parameters in endarterectomized chimpanzees

Parameters*	Control (mean ± SD, n = 5)	ALT-836 (mean ± SD, n = 5)	P
Bleeding Time (min)	2.0 ± 0.2	2.5 ± 0.6	ns
Surgical Blood Loss (mL)	5.9 ± 2.2	4.7 ± 3.0	ns
PT Time (sec):
Pre-Surgery Baseline	nd	11.2 ± 0.7	nd
5 minutes post RF	nd	180 ± 40	0.0001
15 minutes post RF	nd	157 ± 52	0.0001
30 minutes post RF	nd	161 ± 60	0.0001
60 minutes post RF	nd	177 ± 27	0.0001
90 minutes post RF	nd	202 ± 7.7	0.0001
24 hours post RF	nd	18.1 ± 5.1	0.036
Platelet Count (×103/μL):
Pre-Surgery Baseline	222 ± 73	233 ± 52	ns
24 hours Post Surgery	273 ± 61	247 ± 90	ns
WBC (×103/μL):
Pre-Surgery Baseline	7.8 ± 1.5	9.8 ± 1.8	ns
24 hours Post Surgery	18.1 ± 4.5	19.7 ± 6.5	ns

ns, not significant; P < 0.05 considered statistically significant nd, not determined

^*post RF, post restoration of flow following conclusion of endarterectomy