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Leptin suppresses GLP-1-stimulated proinsulin mRNA levels in human islets in the presence of both normal (5.6 mM) and high (11.1 mM) glucose. Human islets were incubated for 16 h in the presence of normal (5.6 mM) or high (11.1 mM) glucose with and without 6.25 nM leptin and 10 nM GLP-1. The amounts of proinsulin and actin mRNAs were evaluated as described in Fig. 2 and Materials and Methods.
