TABLE 1.

Suppression of insulin secretion by leptin in cultured human pancreatic islets

	n	Glucose (5.6 mmol/L)		Glucose (11.1 mmol/L)
		Control	Leptina	Control	Leptin
Exp 1	3	7.06b	5.87	15.06	13.2
Exp 2	3	7.67	5.70	10.40	9.80
Exp 3	6	9.24	7.36	14.44	16.5
Compiled mean	12	7.99	6.31	13.30	13.17
SEMc		0.65	0.53	1.46	1.93
P (by t test)			<0.01		<0.46

Insulin released into culture media (nanograms per mL) after 1 hr of treatment with leptin or vehicle alone (control) was measured by RIA.

^aLeptin concentration of 6.25 nmol/L.

^bMeans of the numbers (n) shown.

^cBy Student’s paired t test.