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. 2010 Jul;120(1-3):177–183. doi: 10.1016/j.schres.2010.03.006

Table 2.

Association between maternal folate intake during pregnancy and PLIKS.

Unadjusted
 Adjusted
OR [95% CI] P PSex OR [95% CI] P PSex
All (N = 5344, Cases = 592)
FS18a 1.31 [0.99;1.72] 0.063 0.37 1.34 [1.00;1.76] 0.047 0.38
FS32a 1.08 [0.87;1.33] 0.49 0.23 1.11 [0.90;1.38] 0.32 0.26
Folateb 0.99 [0.91;1.09] 0.89 0.13 1.03 [0.93;1.12] 0.60 0.19
Folate deficiencyc 0.99 [0.81;1.20] 0.89 0.53 0.92 [0.75;1.12] 0.40 0.71



Boys (N = 2613, Cases = 280)
FS18a 1.49 [1.00;2.17] 0.052 – 1.50 [1.00;2.19] 0.051 –
FS32a 1.22 [0.91;1.63] 0.18 – 1.22 [0.90;1.64] 0.19 –
Folateb 1.07 [0.94;1.22] 0.32 – 1.08 [0.95;1.24] 0.23 –
Folate deficiencyc 0.92 [0.69;1.23] 0.58 – 0.90 [0.67;1.20] 0.48 –



Girls (N = 2731, Cases = 312)
FS18a 1.15 [0.76;1.69] 0.48 – 1.19 [0.78;1.75] 0.40 –
FS32a 0.95 [0.69;1.27] 0.72 – 0.99 [0.72;1.35] 0.97 –
Folateb 0.93 [0.82;1.05] 0.25 – 0.97 [0.86;1.11] 0.69 –
Folate deficiencyc 1.05 [0.80;1.37] 0.74 – 0.93 [0.71;1.22] 0.60 –

Models were adjusted for potential maternal confounders (parity, age at birth of the study child, cigarette smoking and alcohol consumption during the first three months of pregnancy, family history of depression, education), occupational social class, housing tenure and offspring sex (complete sample only).

FS18/FS32 — Folate supplementation at 18 or 32- weeks gestation; OR — Odds ratio; Folate — Maternal dietary folate intake at 32 weeks gestation; Folate deficiency — High-risk folate deficiency score; PSex — Sex specific effect; SD — Standard deviation.

a

ORs are given for presence vs. absence of folate supplementation.

b

ORs are given for an increase in one SD of dietary folate intake.

c

ORs are given for an increase in one score unit.