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Indirect calorimetry results after 60 h of fasting in the basal state and upon the hyperinsulinemic-euglycemic clamp. A shows that metabolic flexibility, defined as the change in respiratory exchange ratio upon insulin stimulation, is blunted upon prolonged fasting. B and C display whole-body lipid and carbohydrate oxidation, respectively. White bars/circles represent the fed condition; black bars/circles represent the fasted condition. Values are mean ± SE. *P < 0.05.
