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HGP during hyperinsulinemic-euglycemic clamp is impaired in PANDER−/− mice. HPG during the hyperinsulinemic-euglycemic clamps was determined by subtracting the glucose infusion rate from the whole-body glucose appearance. Male mice ∼5–7 months old were evaluated (n = 8). A: Basal HGP and production at the end of the hyperinsulinemic-euglycemic clamps. B: HGP suppression. Values are means ± SE. *P < 0.05 by Student t test. KO, knockout; WT, wild-type.
