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Abnormal calcium response to glucose stimulation in PANDER−/− islets. Intracellular calcium concentration was determined via fura-2 fluorescence imaging during a glucose perifusion on isolated PANDER−/− and WT islets with stimulation from a glucose ramp and KCl (n = 3). Time of glucose increase is shown above and on the x-axis. Representative calcium plots are shown. Values are means ± SE.
