FIG. 7.

Decreased insulin clearance in PANDER^−/− mice. Intraperitoneal GTT performed by injecting mice with glucose at 2 g/kg and measuring serum insulin and C-peptide concentrations at the indicated time points. Male mice ∼5–7 months old were evaluated (n = 3–6). Insulin (A) and C-peptide (B) serum concentrations were determined with commercially available ELISA (ALPCO). C: C-peptide–to–insulin ratio based on AUC calculated from glycemic levels of insulin and C-peptide measured during the course of the GTT. Values are means ± SE. *P < 0.05 by Student t test.