FIG. 6.

Retinal morphology and morphometry in conditional VEGF KO mice 6 months after onset of diabetes. A and B: Morphology of H&E-stained retinal sections. C: Thickness of outer nuclear layer, inner nuclear layer, and total retina. D and E: Representative TEM images showing no detectable defects in diabetic retina of conditional VEGF KO mice. F: Average number of ganglion cells. Scale bar equals 50 μm in B and 1 μm in d and E. No detectable changes in retinal thickness, numbers of ganglion cells, and retinal ultrastructure were observed in diabetic conditional VEGF KO mice. Ch, choroid; CC, choriocapillaris; GC, ganglion cells; INL, inner nuclear layer; ns, not significant; ONL, outer nuclear layer; P, photoreceptors.