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. 2010 Jun 21;59(9):2306–2314. doi: 10.2337/db09-1727

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Wound healing. Healing of a 4-mm–diameter cutaneous wound was monitored using digital photography in wild-type (WT) and p66Shc-knockout (KO) diabetic (DM) and nondiabetic (ND) mice with or without hind limb ischemia. Representative photos are shown. Wound size is reported as fraction of the initial wound area. On the right, healing time is shown for WT and p66Shc^−/− mice with or without diabetes and limb ischemia on the SV129 or the C57BLC57BL/6 background at 4 or 12 weeks of diabetes duration. n ≥ 3 mice for each group. *P < 0.05 in KO vs. WT. (A high-quality digital representation of this figure is available in the online issue.)