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. 2010 Jun 21;59(9):2315–2325. doi: 10.2337/db10-0638

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Changes of retinal VEGF levels in the control rats (control), diabetic rats (DM), and diabetic rats treated with simvastatin (DM + S). A: Real-time RT-PCR determination of VEGF mRNAs relative to the control values. B: Western blot analysis of VEGF protein expression in the three groups. Equal protein loading was confirmed by detection of β-actin. C: Retinal vascular permeability in the three groups. Bars indicate SD. A representative experiment of the three is shown (**P < 0.01 vs. control; ##P < 0.01 vs. DM; n = 8).