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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Mol Psychiatry. 2006 Jun 27;11(11):992–1002. doi: 10.1038/sj.mp.4001863

Figure 5.

Figure 5

Restraint stress does not induce pCREB expression in adult hippocampus. (a) Unlike the immature hippocampus, numerous stress-free adult hippocampal neurons express pCREB. (b) A 30 min restraint stress does not influence this pCREB expression in saline-preinfused controls. (c) CRF1 antagonists prior to stress also have no significant effect on pCREB expression (see Figure 1 for the time-plan of antagonist infusions). (d) The restraint is a significant stress, leading to an increase in plasma corticosterone levels, and this stress-evoked glucocorticoid secretion is not influenced by icv infusion of saline, NBI 30775 or α-helical CRH, suggesting that central infusion of CRF1 antagonists does not block the peripheral stress response. Scale bar = 720 μm (a–c).