Table 2.

The IRF model parameters and fitted TCM parameters for all simulated cases. For muscle, the average values of the EMM parameters were used and this muscle curve was also used to derive the AIF.

Case	K	λ	ρ	κ1	ε	κ2	R2	Ktrans	ve	R2
Muscle	0.11	20.5	0.12	0.54	0.003	0.12	0.99	0.11	0.20	0.99
Tumor (a)	0.27	4.6	0.22	0.43	0.10	0.05	0.99	0.26	0.81	0.98
A = 0.5	0.07	4.6	0.22	0.43	0.10	0.05	0.99	0.07	0.20	0.98
A = 3.5	0.47	5.3	0.16	0.43	0.09	0.05	0.99	0.52	1.00	−1.57
q = 0.5	0.27	25.5	0.03	0.49	0.14	0.07	0.96	0.29	0.80	0.66
q = 1.5	0.29	2.8	0.49	0.44	0.09	0.05	0.99	0.24	0.83	0.96
α = 0.25	0.11	0.80	0.63	0.16	0.20	0.05	0.99	0.09	1.00	0.93
α = 3.75	0.29	52.1	0.26	0.54	0.14	0.08	0.98	0.30	0.80	0.78
β = −0.005	0.26	6.0	0.17	0.42	0.12	0.02	0.99	0.26	0.92	0.95
β = 0.025	0.27	9.8	0.15	0.41	0.04	0.10	0.99	0.27	0.73	0.99
γ = 0.0	0.26	5.4	0.16	0.43	0.16	0.03	0.99	0.25	0.98	0.95
γ = 0.1	0.28	5.2	0.16	0.44	0.04	0.02	0.99	0.27	0.71	0.99
Tumor (s)	0.03	0.3	0.95	0.14	0.36	0.007	0.99	0.02	1.00	0.90
Tumor (f)	0.61	39.1	0.01	0.71	0.09	0.19	0.97	0.65	1.00	0.45

For tumors, the average values of the EMM parameters were used first, (referred to as Tumor (a) in the table). Then specific parameters (i.e. A, q, α, β, or γ) were set to their average values plus and minus one standard deviation. To simulate slow uptake combined with slow washout (referred to as Tumor (s) in the table), the values of [A, q, α, β, t γ] = [0.5, 1.5, 0.25, −0.005, 0.0] were used. To simulate fast uptake combined with fast washout (Tumor (f) in the table), the values [A, q, α, β, γ] = [3.5, 0.5, 3.75, 0.025, 0.1] were used.