Table 3.
Clinico-epidemiological variables of the 86 colorectal carcinoma patients versus 16 mutant phenotypes of SMAD4 gene
| Variable | Total N = 86 | Mutants M = 16 (18.6%) | P value* |
|---|---|---|---|
| Age group | |||
| ≤60 | 52(60.5%) | 11(21.2%) | NS |
| >60 | 34(39.5%) | 5(14.7%) | |
| Gender | |||
| Female | 37 (43.0%) | 7 (18.9%) | NS |
| Male | 49 (67.0%) | 9 (18.4%) | |
| Dwelling | |||
| Rural | 59 (68.6%) | 12 (20.3%) | NS |
| Urban | 27 (31.4%) | 4 (14.8%) | |
| Tumor location | |||
| Colon | 36 (41.9%) | 12 (33.3%) | <0.01 |
| Rectum | 50 (58.1%) | 4 (8.0% | |
| Nodal status | |||
| Involved | 48 (55.8%) | 14 (29.2%) | <0.01 |
| Not Involved | 38 (44.2%) | 2 (5.3%) | |
| Tumor grade | |||
| A + B | 38 (44.2%) | 2 (5.3%) | <0.01 |
| C + D | 48 (55.8%) | 14 (29.2%) | |
| Smoking status | |||
| Ever | 55 (64.0%) | 13 (23.6%) | NS |
| Never | 31 (36.0%) | 3 (9.6%) | |
| Bleeding PR/Constipation | |||
| Yes | 60 (69.8%) | 15 (25.0%) | <0.01 |
| No | 26 (30.2%) | 1 (3.8%) | |
| Pesticide Exposure | |||
| Ever | 53 (61.6%) | 13 (24.5%) | <0.05 |
| Never | 33 (38.4%) | 3 (9.1%) | |
| KRAS Status | |||
| Wild-type | 65 (75.6%) | 5 (7.7%) | < 0.01 |
| Mutated | 21 (24.4%) | 11 (52.4%) | |
*Pearson's two proportion test