Table 5.
Comparison of cumulative incidence of predominant progression sites between one extranodal disease in the breast and multiple extranodal disease group according to suggested criteria
| Disease classification | No. | 1-year | 3-year | 5-year | P value | |
|---|---|---|---|---|---|---|
| LNs only | OED | 1 | 2.7 ± 2.7 | 2.7 ± 2.7 | 2.7 ± 2.7 | 0.062 |
| MED | 2 | 7.7 ± 7.4 | 10.2 ± 8.2 | 10.2 ± 8.2 | ||
| Breast (±LNs, ±CNS) | OED | 6 | 7.8 ± 4.3 | 11.9 ± 5.8 | 16.6 ± 7.1 | 0.902 |
| MED | 2 | 13.7 ± 9.2 | 13.7 ± 9.2 | 13.7 ± 9.2 | ||
| CNS (±LNs, ± other extranodal diseases, but not LNs only and | OED | 4 | 5.5 ± 3.8 | 8.7 ± 4.8 | 12.3 ± 8.5 | 0.411 |
| breast) | MED | 2 | 12.5 ± 8.3 | 12.5 ± 8.3 | 12.5 ± 8.3 | |
| Extranodal diseases (±LNs, ≥2 or other than | OED | 3 | 2.9 ± 2.8 | 9.7 ± 5.4 | 9.7 ± 5.4 | 0.001 |
| breast and CNS) | MED | 6 | 38.7 ± 14.2 | 49.0 ± 15.1 | 49.0 ± 15.1 | |
Values are expressed as cumulative incidence (%) ± standard error unless stated otherwise. Abbreviations: OED, one extranodal disease in the breast; MED, multiple extranodal disease; LNs, lymph nodes; CNS, central nervous system.