Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1966 Aug;45(8):1255–1267. doi: 10.1172/JCI105432

Production of bile duct hyperplasia and gallstones by lithocholic acid.

R H Palmer, Z Ruban
PMCID: PMC292801  PMID: 5923701

Full text

PDF
1256

Images in this article

1256Image
on p.1256
1257Image
on p.1257
1257Image
on p.1257
1257Image
on p.1257
1258Image
on p.1258
1258Image
on p.1258
1258Image
on p.1258
1258Image
on p.1258
1259Image
on p.1259
1259Image
on p.1259

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGERET B., CHATAGNER F. Influence d'une carence en vitamine B6 sur la teneur en acides tauro-conjugués et glyco-conjugués de la bile du rat. Biochim Biophys Acta. 1956 Nov;22(2):273–277. doi: 10.1016/0006-3002(56)90151-2. [DOI] [PubMed] [Google Scholar]
  2. BEVANS M., MOSBACH E. H. Biological studies of dihydrocholesterol; production of biliary concrements and inflammatory lesions of the biliary tract in rabbits. AMA Arch Pathol. 1956 Aug;62(2):112–117. [PubMed] [Google Scholar]
  3. Carey J. B., Jr, Williams G. Lithocholic acid in human-blood serum. Science. 1965 Oct 29;150(3696):620–622. doi: 10.1126/science.150.3696.620. [DOI] [PubMed] [Google Scholar]
  4. DANIELSSON H., ENEROTH P., HELLSTROM K., LINDSTEDT S., SJOVALL J. On the turnover and excretory products of cholic and chenodeoxycholic acid in man. J Biol Chem. 1963 Jul;238:2299–2304. [PubMed] [Google Scholar]
  5. DAWSON A. M., ISSELBACHER K. J. Studies on lipid metabolism in the small intestine with observations on the role of bile salts. J Clin Invest. 1960 May;39:730–740. doi: 10.1172/JCI104090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. ENEROTH P. THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS. J Lipid Res. 1963 Jan;4:11–16. [PubMed] [Google Scholar]
  7. Eyssen H., Vandeputte M., Evrard E. Effect of various dietary bile acids on nutrient absorption and on liver size in chicks. Arch Int Pharmacodyn Ther. 1965 Dec;158(2):292–306. [PubMed] [Google Scholar]
  8. FRY R. J., STAFFELDT E. EFFECT OF A DIET CONTAINING SODIUM DEOXYCHOLATE ON THE INTESTINAL MUCOSA OF THE MOUSE. Nature. 1964 Sep 26;203:1396–1398. doi: 10.1038/2031396a0. [DOI] [PubMed] [Google Scholar]
  9. GAENSHIRT H., KOSS F. W., MORIANZ K. [Studies on the quantitative evaluation of thin-layer chromatography. 2. Separation and determination of bile acids]. Arzneimittelforschung. 1960 Nov;10:943–947. [PubMed] [Google Scholar]
  10. Gallagher T. F., Jr, Mueller M. N., Kappas A. Studies on the mechanism and structural specificity of the estrogen effect on BSP metabolism. Trans Assoc Am Physicians. 1965;78:187–195. [PubMed] [Google Scholar]
  11. HAMBRE C. J. Dilatation of the bile ducts and intrahepatic lesions with obstructive jaundice in rats fed diets deficient in vitamin A. Am J Med Sci. 1950 Aug;220(2):183–194. [PubMed] [Google Scholar]
  12. HASLEWOOD G. A. Recent developments in our knowledge of bile salts. Physiol Rev. 1955 Jan;35(1):178–196. doi: 10.1152/physrev.1955.35.1.178. [DOI] [PubMed] [Google Scholar]
  13. HAUTON J. C., GREUSARD C., PERROT M. J., SARLES H. [Determination of the bile acids of the bile by chromatography with polarity gradient]. Bull Soc Chim Biol (Paris) 1962;44:1153–1159. [PubMed] [Google Scholar]
  14. HOFMANN A. F., MOSBACH E. H. IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL. J Biol Chem. 1964 Sep;239:2813–2821. [PubMed] [Google Scholar]
  15. HOLT P. R., HAESSLER H. A., ISSELBACHER K. J. Effects of bile salts on glucose metabolism by slices of hamster small intestine. J Clin Invest. 1963 Jun;42:777–786. doi: 10.1172/JCI104770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. HUNT R. D., LEVEILLE G. A., SAUBERLICH H. E. DIETARY BILE ACIDS AND LIPID METABOLISM. III. EFFECTS OF LITHOCHOLIC ACID IN MAMMALIAN SPECIES. Proc Soc Exp Biol Med. 1964 Feb;115:277–280. doi: 10.3181/00379727-115-28890. [DOI] [PubMed] [Google Scholar]
  17. HUNT R. D., LEVEILLE G. A., SAUBERLICH H. E. Dietary bile acids and lipid metabolism. II. The ductular cell reaction induced by lithocholic acid. Proc Soc Exp Biol Med. 1963 May;113:139–142. doi: 10.3181/00379727-113-28300. [DOI] [PubMed] [Google Scholar]
  18. HURLOCK B., TALALAY P. Enzymatic estimation of steroids in human urine. Endocrinology. 1958 Feb;62(2):201–215. doi: 10.1210/endo-62-2-201. [DOI] [PubMed] [Google Scholar]
  19. IWATA T., YAMASAKI K. ENZYMATIC DETERMINATION AND THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS IN BLOOD. J Biochem. 1964 Nov;56:424–431. doi: 10.1093/oxfordjournals.jbchem.a128013. [DOI] [PubMed] [Google Scholar]
  20. KARNOVSKY M. J. Simple methods for "staining with lead" at high pH in electron microscopy. J Biophys Biochem Cytol. 1961 Dec;11:729–732. doi: 10.1083/jcb.11.3.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. KUKSIS A. GAS-LIQUID CHROMATOGRAPHY OF BILE ACIDS. J Am Oil Chem Soc. 1965 Apr;42:276–282. doi: 10.1007/BF02540129. [DOI] [PubMed] [Google Scholar]
  22. MUELLER M. N., KAPPAS A. ESTROGEN PHARMACOLOGY. I. THE INFLUENCE OF ESTRADIOL AND ESTRIOL ON HEPATIC DISPOSAL OF SULFOBROMOPHTHALEIN (BSP) IN MAN. J Clin Invest. 1964 Oct;43:1905–1914. doi: 10.1172/JCI105064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. NORMAN A., PALMER R. H. METABOLITES OF LITHOCHOLIC ACID-24-C-14 IN HUMAN BILE AND FECES. J Lab Clin Med. 1964 Jun;63:986–1001. [PubMed] [Google Scholar]
  24. PALMER R. H. GALLSTONES PRODUCED EXPERIMENTALLY BY LITHOCHOLIC ACID IN RATS. Science. 1965 Jun 4;148(3675):1339–1340. doi: 10.1126/science.148.3675.1339. [DOI] [PubMed] [Google Scholar]
  25. PALMER R. H., GLICKMAN P. B., KAPPAS A. Pyrogenic and inflammatory properties of certain bile acids in man. J Clin Invest. 1962 Aug;41:1573–1577. doi: 10.1172/JCI104614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. PALMER R. H. HAEMOLYTIC EFFECTS OF STEROIDS. Nature. 1964 Mar 14;201:1134–1135. doi: 10.1038/2011134b0. [DOI] [PubMed] [Google Scholar]
  27. PALMER R. H. INFLAMMATORY EFFECTS OF PYROGENIC STEROIDS IN ANIMALS. Proc Soc Exp Biol Med. 1965 May;119:108–111. doi: 10.3181/00379727-119-30110. [DOI] [PubMed] [Google Scholar]
  28. PERIC-GOLIA L., JONES R. S. ORNITHOCHOLANIC ACIDS AND CHOLELITHIASIS IN MAN. Science. 1963 Oct 11;142(3589):245–246. doi: 10.1126/science.142.3589.245. [DOI] [PubMed] [Google Scholar]
  29. PERIC-GOLIA L., JONES R. S. Ornithocholanic acids--abnormal conjugates of bile acids. Proc Soc Exp Biol Med. 1962 Jun;110:327–331. doi: 10.3181/00379727-110-27506. [DOI] [PubMed] [Google Scholar]
  30. ROSENFELD R. S., HELLMAN L. Excretion of steroid acids in man. Arch Biochem Biophys. 1962 May;97:406–410. doi: 10.1016/0003-9861(62)90097-8. [DOI] [PubMed] [Google Scholar]
  31. RUBINSTEIN H. M., PRYCE J. D. The colorimetric estimation of alpha-amino nitrogen in tissue fluids. J Clin Pathol. 1959 Jan;12(1):80–84. doi: 10.1136/jcp.12.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. SANDBERG D. H., SJOEVALL J., SJOEVALL K., TURNER D. A. MEASUREMENT OF HUMAN SERUM BILE ACIDS BY GAS-LIQUID CHROMATOGRAPHY. J Lipid Res. 1965 Apr;6:182–192. [PubMed] [Google Scholar]
  33. STEWART F. S., PEARSON A. E. Estimation of mouse tumour blood volumes employing a radioactive isotope technique. Nature. 1960 Apr 16;186:250–251. doi: 10.1038/186250b0. [DOI] [PubMed] [Google Scholar]
  34. THOMAS P. J., HSIA S. L., MATSCHINER J. T., DOISY E. A., Jr, ELLIOTT W. H., THAYER S. A., DOISY E. A. BILE ACIDS. XIX. METABOLISM OF LITHOCHOLIC ACID-24-14C IN THE RAT. J Biol Chem. 1964 Jan;239:102–105. [PubMed] [Google Scholar]
  35. WEINER I. M., GLASSER J. E., LACK L. RENAL EXCRETION OF BILE ACIDS: TAUROCHOLIC, GLYCOCHOLIC, AND COLIC ACIDS. Am J Physiol. 1964 Nov;207:964–970. doi: 10.1152/ajplegacy.1964.207.5.964. [DOI] [PubMed] [Google Scholar]
  36. WISSLER R. W., FRAZIER L. F., SOULES K. H., BARKER P., BRISTOW E. C., 3rd The acute effects of beta3 thienylalanine in the adult male albino rat; observations on nitrogen balance, antibody formation, and tumor growth. AMA Arch Pathol. 1956 Jul;62(1):62–73. [PubMed] [Google Scholar]
  37. WOOTTON I. D., WIGGINS H. S. Studies in the bile acids. 2. The non-ketonic acids of human bile. Biochem J. 1953 Sep;55(2):292–294. doi: 10.1042/bj0550292. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES