FIG. 2.

Levels of viral load do not correlate with the amount of TRAIL that is released in HIV⁺CD4^low and HIV⁺CD4^high patients. PBMCs of 12 HIV-infected subjects with CD4⁺ T cell counts below 200 CD4⁺ T cells/mm³ (HIV⁺CD4^low) (A) and 8 donors with CD4⁺ T cell counts above 200 CD4 cells/mm³ (HIV⁺CD4^high) (B) were tested directly ex vivo in a TRAIL ELISPOT assay in the presence of an HIV peptide library as described in the legend to Fig. 1. The cumulative number of TRAIL spots induced by all individual peptides within the specific peptide library is represented by the symbols for each donor. The results were correlated with the viral load levels as measured by RT-PCR in each individual donor.