FIG. 4.

(A) Principal component analysis and (B) heat map generated from microarray data showing differential gene expression (green indicates greater; red indicates lower) between undifferentiated MSCs at day 0 (M0), chondrogenically differentiated MSC-seeded constructs at day 28 (M28), and chondrocyte-seeded constructs at day 28 (C28). (C, D) Venn diagrams and (E–G) volcano plots for M0, M28, and C28 indicates number of genes and dispersion of genes that were differentially regulated with chondrogenic induction in three-dimensional culture. Color images available online at www.liebertonline.com/ten.