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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Oncogene. 2007 Sep 17;27(10):1366–1375. doi: 10.1038/sj.onc.1210783

Figure 5.

Figure 5

Autophagic features of BIK-induced cell death. (a) Distribution of LC3 in cells transfected with BIK (±zVAD-fmk). (b) Role of BIK BH3 domain on cell death. Cells were infected with Ad-LacZ or Ad-BIK or Ad-BIKΔBH3 (±zVAD-fmk) and viabilities were determined after 48 h; n = 3. (c) Quantification of cells showing punctate distribution of LC3; n = 3. At least 150 cells per sample were examined at random. (d) Immunofluorescence analysis of LC3 distribution. (e) Expression of Beclin-1 in BIK-expressing Bcl-2−/− cells treated with zVAD-fmk.