Table 5.
Univariate and adjusted analysis of CTLA4 tagging SNPs
| Controls, n (%) |
BCC, n (%) |
Univariate OR (95% CI) |
Adjusted OR (95% CI)* |
SCC, n (%) |
Univariate OR (95% CI) |
Adjusted OR (95% CI)* |
|
|---|---|---|---|---|---|---|---|
| rs16840252 | |||||||
| CC | 565 (68.3) | 631 (69.8) | Reference | Reference | 483 (70.7) | Reference | Reference |
| CT | 236 (28.5) | 249 (27.5) | 0.9 (0.8–1.2) | 1.0 (0.8–1.2) | 183 (26.8) | 0.9 (0.7–1.1) | 0.9 (0.7–1.1) |
| TT | 26 (3.1) | 24 (2.7) | 0.8 (0.5–1.5) | 0.8 (0.4–1.3) | 17 (2.5) | 0.8 (0.4–1.4) | 0.6 (0.3–1.1) |
| rs231731 | |||||||
| TT | 520 (62.9) | 580 (63.8) | Reference | Reference | 453 (65.1) | Reference | Reference |
| CT | 272 (32.9) | 292 (32.1) | 1.0 (0.8–1.2) | 1.0 (0.8–1.2) | 212 (30.5) | 0.9 (0.7–1.1) | 0.9 (0.7–1.1) |
| CC | 35 (4.2) | 37 (4.1) | 0.9 (0.6–1.5) | 0.9 (0.6–1.5) | 31 (4.5) | 1.0 (0.6–1.7) | 0.9 (0.6–1.6) |
| rs11571317 | |||||||
| CC | 679 (86.4) | 743 (85.4) | Reference | Reference | 561 (86.3) | Reference | Reference |
| CT | 99 (12.6) | 114 (13.1) | 1.1 (0.8–1.4) | 1.0 (0.7–1.3) | 83 (12.8) | 1.0 (0.7–1.4) | 0.9 (0.7–1.3) |
| TT | 8 (1.0) | 13 (1.5) | 1.5 (0.6–3.6) | 1.5 (0.6–3.7) | 6 (0.9) | 0.9 (0.3–2.6) | 1.0 (0.3–3.1) |
| rs733618 | |||||||
| AA | 706 (84.9) | 782 (86.1) | Reference | Reference | 592 (85.1) | Reference | Reference |
| GA | 122 (14.7) | 121 (13.3) | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 99 (14.2) | 1.0 (0.7–1.3) | 1.0 (0.8–1.4) |
| GG | 4 (0.5) | 5 (0.6) | 1.1 (0.3–4.2) | 1.4 (0.3–5.9) | 5 (0.7) | 1.5 (0.4–5.6) | 2.0 (0.5–8.5) |
| rs5742909 | |||||||
| CC | 682 (83.1) | 745 (82.4) | Reference | Reference | 561 (81.7) | Reference | Reference |
| CT | 132 (16.1) | 152 (16.8) | 1.1 (0.8–1.4) | 1.1 (0.8–1.4) | 120 (17.5) | 1.1 (0.8–1.5) | 1.0 (0.8–1.4) |
| TT | 7 (0.9) | 7 (0.8) | 0.9 (0.3–2.6) | 1.0 (0.3–2.8) | 6 (0.9) | 1.0 (0.3–3.1) | 1.0 (0.3–3.1) |
| rs3087243 (CT60) | |||||||
| AA | 156 (19.0) | 207 (23.0) | Reference | Reference | 143 (20.7) | Reference | Reference |
| AG | 385 (46.9) | 442 (49.1) | 0.9 (0.7–1.1) | 0.9 (0.7–1.1) | 349 (50.6) | 1.0 (0.8–1.3) | 1.0 (0.7–1.3) |
| GG | 280 (34.1) | 252 (28.0) | 0.7 (0.5–0.9) | 0.7 (0.5–0.9) | 198 (28.7) | 0.8 (0.6–1.0) | 0.7 (0.5–1.0) |
| rs231775 | |||||||
| AA | 318 (38.8) | 388 (43.3) | Reference | Reference | 272 (39.8) | Reference | Reference |
| AG | 353 (43.1) | 388 (43.3) | 0.9 (0.7–1.1) | 0.9 (0.7–1.2) | 319 (46.6) | 1.1 (0.8–1.3) | 1.1 (0.9–1.4) |
| GG | 148 (18.1) | 121 (13.5) | 0.7 (0.5–0.9) | 0.7 (0.5–0.9) | 93 (13.6) | 0.7 (0.5–1.0) | 0.7 (0.5–1.0) |
| rs231777 | |||||||
| CC | 590 (72.7) | 663 (74.2) | Reference | Reference | 506 (74.2) | Reference | Reference |
| CT | 205 (25.3) | 211 (23.6) | 0.9 (0.7–1.1) | 0.9 (0.7–1.2) | 159 (23.3) | 0.9 (0.7–1.1) | 0.9 (0.7–1.1) |
| TT | 17 (2.1) | 20 (2.2) | 1.0 (0.5–2.0) | 1.0 (0.5–1.9) | 17 (2.5) | 1.2 (0.6–2.3) | 0.9 (0.5–1.9) |
*
ORs adjusted for gender, age at tumor diagnosis, skin reaction to acute sun exposure, and lifetime number of severe sunburns.