Table 6.

Estimated haplotypes of CTLA4 and association with SCC and BCC

Haplotypes	Tagging SNPs	Frequency (%)*		OR (95% CI) † , ‡	Frequency (%)*	OR (95% CI) † , ‡
	1-2-3-4-5-6-7-8	Controls	BCC		SCC
H1	0-0-0-0-0-1-0-0	0.353	0.393	Reference	0.386	Reference
H2	0-0-0-0-0-0-1-0	0.316	0.283	0.8 (0.7–0.9)	0.297	0.8 (0.7–1.0)
H3	1-1-0-0-1-0-0-1	0.090	0.092	0.9 (0.7–1.2)	0.097	0.9 (0.7–1.2)
H4	0-0-1-0-0-1-0-0	0.074	0.081	0.9 (0.7–1.2)	0.075	0.9 (0.6–1.2)
H5	1-1-0-0-0-0-0-1	0.059	0.052	0.8 (0.6–1.1)	0.044	0.6 (0.4–0.9)
H6	0-1-0-1-0-0-1-0	0.051	0.052	0.9 (0.7–1.2)	0.052	1.0 (0.7–1.4)
H7	<0.05§	0.056	0.048	0.7 (0.5–1.0)	0.050	0.9 (0.6–1.2)

^*Based on 801 controls, 900 BCC, and 685 SCC.

^†ORs controlled for age at diagnosis, sex, skin reaction to first summer sun exposure for 1 h, and lifetime number of severe sunburns.

^‡Global test on haplotypes: BCC, P = 0.14; SCC, P = 0.12.

^§This category combines other haplotypes generated from these eight tagging SNPs with a frequency below 5%.