Figure S3.

Positional Analysis of Residue Size Moment, Related to Figure 5

(A and B) The size moment at each position of a protein was defined as being the sum of the vector of the volume of that residue and of the vectors of the volumes of the six residues on either side (i.e., a window of seven residues which approximates to two turns of an α helix—see Experimental Procedures). This moment was calculated at each position for each protein and mean values at each position determined for all the proteins in the same dataset. Glycophorin A dimerizes via a GXXXG motif in its TMD and serves as a positive control. The different datasets from the different organelles do not show large differences in size moment, and hence are not differentially enriched in GXXXG-like dimerization motifs.