Table 3.
The SNP genotypes of MMPs and TIMPs in the both genders with different clinical diagnoses
| Genotype | Female | Male | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | Gastritis | DU | GU | P a | P b | Gastritis | DU | GU | P a | P b | |
| MMP-3 | |||||||||||
| 5A carrier | 46 (25.1) | 7 (12.3) | 8 (22.2) | 0.04 | 0.71 | 28 (34.1) | 15 (24.6) | 11 (21.6) | 0.22 | 0.12 | |
| 6A/6a | 137 (74.9) | 50 (87.7) | 28 (77.8) | 54 (65.9) | 46 (75.4) | 40 (78.4) | |||||
| MMP-7 | |||||||||||
| A/A | 150 (82.9) | 45 (80.4) | 32 (91.4) | 0.31 | 72 (88.9) | 52 (86.7) | 39 (76.5) | 0.69 | 0.06 | ||
| G carrier | 31 (17.1) | 11 (19.6) | 3 (8.6) | 0.67 | 9 (11.1) | 8 (13.3) | 12 (23.5) | ||||
| MMP-9 | |||||||||||
| A carrier | 78 (42.6) | 19 (33.3) | 15 (41.7) | 0.21 | 0.92 | 25 (30.5) | 22 (36.1) | 22 (43.1) | 0.48 | 0.14 | |
| G/G | 105 (57.4) | 38 (66.7) | 21 (58.3) | 57 (69.5) | 39 (63.9) | 29 (56.9) | |||||
| TIMP-1 | |||||||||||
| ♀ T carrier | ♂ T | 148 (80.9) | 41 (73.2) | 29 (80.6) | 0.22 | 0.97 | 46 (56.8) | 31 (50.8) | 26 (51.0) | 0.48 | 0.51 |
| C/C | C | 35 (19.1) | 15 (26.8) | 7 (19.4) | 35 (43.2) | 30 (49.2) | 25 (49.0) | ||||
| TIMP-2 | |||||||||||
| C carrier | 54 (30.2) | 17 (32.1) | 10 (28.6) | 0.79 | 0.85 | 27 (33.3) | 20 (32.3) | 13 (25.5) | 0.89 | 0.34 | |
| G/G | 125 (69.8) | 36 (67.9) | 25 (71.4) | 54 (66.7) | 42 (67.7) | 38 (74.5) | |||||
Abbreviations: DU, duodenal ulcer; GU, gastric ulcer. The p value was determined by Fisher's exact test or χ2 test. a indicated significance with p < 0.05 of such parameter between gastritis and duodenal ulcer; b between gastritis and gastric ulcer. Genotype distribution of SNP in cases and control was in Hardy-Weinberg equilibrium (p < 0.05).