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. 2010 Aug 11;7:41. doi: 10.1186/1476-9255-7-41

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Copyright ©2010 Meyer et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CP-690,550 inhibits the increase in bone marrow myeloid precursors in the rat AIA model. Bone marrow from normal and AIA rats (n = 12 rats per group) was analyzed for maturing myeloid precursors by flow cytometry at day 7 and day 21 post-adjuvant immunization (A). (*) indicates statistical significance p ≤ 0.0008 compared to normal animals. AIA rats were treated with CP-690,550 or vehicle control orally, once daily, days 14 to 21, and bone marrow was collected and analyzed on day 21 for maturing myeloid cells by flow cytometry (B). (*) indicates statistical significance p ≤ 0.05 compared to the disease vehicle control. Data represented as the mean ± SEM.