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. 2010 Aug 25;5(8):e12218. doi: 10.1371/journal.pone.0012218

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Bohn, Heermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Shown are the results for equilibrated fibers of length with different looping probabilities. For each parameters set (A. linear chains (no loops), B. on average 19 loops per conformation and C. on average 130 loops per conformation) co-localized beads were determined and marked by a black square. For each image, the contacts of 4 independent polymer conformations are plotted. Linear chains (A) have not so many contacts between beads which are widely separated along the contour of the polymer. Increasing the probability of functional loops (B and C) results in a boost of contacts both between close-by segments as well as between segments having a large genomic separation.

Inline graphic — Shown are the results for equilibrated fibers of length with different looping probabilities. For each parameters set (A. linear chains (no loops), B. on average 19 loops per conformation and C. on average 130 loops per conformation) co-localized beads were determined and marked by a black square. For each image, the contacts of 4 independent polymer conformations are plotted. Linear chains (A) have not so many contacts between beads which are widely separated along the contour of the polymer. Increasing the probability of functional loops (B and C) results in a boost of contacts both between close-by segments as well as between segments having a large genomic separation.