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. 2010 Aug 25;5(8):e12218. doi: 10.1371/journal.pone.0012218

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Bohn, Heermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The following experimental data is shown: Human fibroblasts Chr1 [12]: red ▪ anti-ridge region, green ▪ ridge region, long distance measurements; Human fibroblast Chr 11 [12]: long distance measurements; Murine Igh locus [27]: dark blue ⧫ pre-pro-B cells, light blue ⧫ pro-B cells. The data displays strong deviations towards larger fluctuations in comparison to the random walk (RW), self-avoiding walk (SAW) and globular state (GS) polymer model. B. Results are shown for simulated polymers of various length ( and ) in relation to the average number of loops per monomer, which is related to the looping probability but allows for a better comparison. Although incorporating full excluded volume interactions, fluctuations exceed the random walk value due to probabilistic looping.

Inline graphic — A. The following experimental data is shown: Human fibroblasts Chr1 [12]: red ▪ anti-ridge region, green ▪ ridge region, long distance measurements; Human fibroblast Chr 11 [12]: long distance measurements; Murine Igh locus [27]: dark blue ⧫ pre-pro-B cells, light blue ⧫ pro-B cells. The data displays strong deviations towards larger fluctuations in comparison to the random walk (RW), self-avoiding walk (SAW) and globular state (GS) polymer model. B. Results are shown for simulated polymers of various length ( and ) in relation to the average number of loops per monomer, which is related to the looping probability but allows for a better comparison. Although incorporating full excluded volume interactions, fluctuations exceed the random walk value due to probabilistic looping.