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. 2010 Aug 25;5(8):e12218. doi: 10.1371/journal.pone.0012218

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Bohn, Heermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Simulations were performed in a system with density and chains with a coarse-grained length . Any contact between two beads is represented by a square in the contact map. Statistics is taken over 5 independent conformations. Not the complete contact map is shown, but only contacts between 10 chains. Linear chains (A) display a lot of intermingling and have abundant contacts with other polymers. The fraction of inter-chromosomal contacts is 15.4%. Increasing the loop-size (B and C) results in more and more confined structures, which are depleted of inter-chromosomal interactions. In (B) chains have on average 45 functional loops (blue ▴ in Fig. 7A), the fraction of inter-chromosomal contacts is reduced to 1.8%. This value decreases even more for chains with an average of 92 loops per conformation (1%, green ▴ in Fig. 7A).

Inline graphic — Simulations were performed in a system with density and chains with a coarse-grained length . Any contact between two beads is represented by a square in the contact map. Statistics is taken over 5 independent conformations. Not the complete contact map is shown, but only contacts between 10 chains. Linear chains (A) display a lot of intermingling and have abundant contacts with other polymers. The fraction of inter-chromosomal contacts is 15.4%. Increasing the loop-size (B and C) results in more and more confined structures, which are depleted of inter-chromosomal interactions. In (B) chains have on average 45 functional loops (blue ▴ in Fig. 7A), the fraction of inter-chromosomal contacts is reduced to 1.8%. This value decreases even more for chains with an average of 92 loops per conformation (1%, green ▴ in Fig. 7A).