Fig. 2.

RNA oxidative damage in the dentate gyrus region of postmortem hippocampus tissue from controls and patients with major depressive disorder (MDD), bipolar disorder or schizophrenia. We assessed the damage to the nucleic acids via immunohistochemical staining with an antibody that recognizes 8-oxo-7,8-dihydroguanosine (8-OHG) in RNA and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-OHdG) in DNA (n = 15 patients per group; original magnification × 40). *p < 0.0167, **p < 0.0033 compared with control. SEM = standard error of the mean.