Table 2.

Brain areas with significantly^* increased activation in patients with schizophrenia compared with controls in the contrast of trials after negative feedback (set shift) versus positive feedback

Brain region	Talairach coordinates			Brodmann area	Z score†	No. of voxels
	x	y	z
Right hemisphere
Anterior cingulate gyrus	10	41	11	32	3.60	23
Anterior cingulate gyrus	10	45	1	32	4.00	91‡
Superior temporal gyrus	61	−32	15	22	3.62	10
Left hemisphere
Superior temporal gyrus	−44	−36	17	41	4.18	53§
Insula	−38	−18	−8	13	3.73	25

^*Determined by 2-sample t test, p < 0.001, uncorrected. Controls revealed no areas of increased brain activation compared with schizophrenia patients.

^†Expressed as the maximum within each area. Local maxima are separated by a minimum of 8 mm.

^‡Cluster-level correction (p < 0.005) for multiple comparisons.

^§Cluster-level correction (p < 0.05) for multiple comparisons.