Table 2.

Wild-Type (wt) and PI Resistance Mutations

Positiona,b	Baseline count (n = 234)	Baseline PI resistance mutations in virologic nonresponders at week 16 (n = 149)c,d	Baseline PI resistance mutations in virologic responders at week 16 (n = 67)c,e	Week 16 PI resistance mutations in virologic nonresponders (n = 141)c,d
10L (wt)	127	71	46	60
10F/I/R/V/Z	14, 87, 6, 9, 2	10, 62, 4, 8, 1	3, 18, 1, 0, 0	10, 72, 1, 6, 0
24L (wt)	210	130	65	118
24I/F/Z	24, 0, 0	19, 0, 0	2, 0, 0	22, 1, 1
36M (wt)	194	122	56	105
36I/L	38, 3	25, 2	10, 1	34, 2
46M (wt)	117	67	39	74
46I/L/V	84, 49, 0	62, 28, 0	19, 15, 0	49, 25, 1
47I (wt)	221	145	60	140
47V	13	4	7	1
48G (wt)	234	149	67	128
48V/Z	0, 0	0, 0	0, 0	11, 2
53F (wt)	229	146	67	118
53L/Y/Z	4, 0, 1	2, 0, 1	2, 0, 0	21, 1, 1
54I (wt)	190	118	57	92
54T/V/A/L	1, 43, 2, 0	0, 30, 1, 0	1, 10, 1, 0	0, 47, 0, 2
63L (wt)	28	15	11	13
63P/Z	181, 33	122, 16	46, 12	117, 16
71A (wt)	139	83	47	66
71T/V/I	32, 64, 5	21, 46, 4	8, 12, 1	16, 59, 6
73G (wt)	202	122	65	103
73C/S/T/Z	4, 23, 5, 1	4, 19, 4, 1	0, 1, 1, 0	5, 30, 9, 4
82V (wt)	117	77	33	82
82A/F/I/S/T	96, 11, 3, 2, 17	61, 4, 1, 2, 11	26, 6, 0, 0, 5	49, 2, 2, 1, 7
84I (wt)	222	139	65	101
84V/A/Z	12, 0, 0	10, 0, 0	2, 0, 0	40, 3, 2
88N (wt)	219	135	66	128
88D/S/T/Z	9, 5, 1, 1	8, 5, 1, 1	1, 0, 0, 0	7, 5, 1
90L (wt)	191	115	59	77
90M	43	34	8	65
93I (wt)	114	72	33	80
93L/Z	120, 1	77, 0	34, 1	61, 0

^aZ represents any other polymorphism different from wild-type.

^bPositions with low frequencies of substitutions that were not significantly different or associated with a virologic response include codons 20, 30, 32, 33, and 50.

^cNumbers in bold font (p value <0.05).

^dVirologic nonresponders = subjects with HIV-1 viral RNA load >500 copies/ml.

^eVirologic responders = subjects with HIV-1 viral RNA load ≥500 copies/ml.