Table 2. Histopathological analyses of inflammatory parameters, demyelination and axonal damage in the spinal cord of C57BL/6 mice at 7, 14, and 23 days after MOG_35–55 EAE induction.

	EAE	EAE+PTx icv	P value
Inflammation (H&E)
day 7	0.25±0.27	0.08±0.20	0.260
day14	3.33±0.75	1.33±0.75	0.001*
day 23	3.42±0.58	1.33±0.68	<0.001*
Demyelination (Fast blue)
day 7	0.25±0.27	0.08±0.20	0.260
day 14	3.66±0.98	0.83±0.98	0.001*
day 23	3.75±0.93	1.16±0.98	0.001*
Axonal loss (silver staining)
day 7	0.83±0.20	0.04±0.10	0.664
day 14	2.42±0.86	0.66±0.51	0.002*
day 23	2.58±0.97	0.58±0.49	0.001*

Data were presented as Mean ± SD.